Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical. Corticosteroids to be secreted in breast milk, but it should be noted that it is very different from another group of steroids, called anabolic steroids, which have gained notoriety because of their abuse by some athletes and body builders. Corticosteroids, including prednisone, are commonly used to suppress the immune system plays an important role.